Born at Westhampnett, Sussex, on 13 June 1792, Lillywhite was already approaching his thirties when he took up serious cricket. His career proper began in 1825 (the conventional starting date used by cricket historians, though he had appeared in lesser fixtures earlier) and ran until his benefit match in 1853. Lillywhite bowled right-arm fast-medium roundarm with an action that contemporaries described as the most rhythmical they had ever seen. He was a small man, less than 5 feet 5 inches tall, and stocky; he bowled all day in a top hat and a black suit and was famous for never tiring. By the late 1820s he was the chief weapon of Sussex, the strongest county in England, and he was the central figure in the trial matches of 1827. Despite the formal inconclusiveness of the trials, his reputation was made; by 1830 the umpires were not no-balling him whatever the height of his arm. Through the 1830s and 1840s he took 100 wickets in a season repeatedly — three consecutive seasons between 1842 and 1844 — and ended his career with over 1,500 first-class wickets, a tally only Alfred Mynn's would seriously rival. The nickname 'Nonpareil' (without equal) was used of him from at least the early 1840s, partly to distinguish him from Fuller Pilch, whom contemporaries called the 'nonpareil hitter'.