Lohmann had been Surrey's senior fast-medium bowler from 1884 and a Test stalwart from 1886. His 200-wickets-a-season run in the late 1880s and the 1895-96 South African series (35 wickets at 5.80, see entries) had made him the most-feared bowler in cricket. Tuberculosis was diagnosed in autumn 1892; the Surrey committee paid for his first South African winter that year.
Through 1893-96 he wintered in Cape Town and played English summers, achieving the 1895-96 South Africa Test series triumph during one such winter. By 1897 the disease had progressed and English summers had become difficult. He emigrated permanently to Cape Town in autumn 1897, played a full first-class season for Western Province, and combined his cricket with sanatorium treatment at the Matjiesfontein hill station, sponsored by the Scottish-born railway entrepreneur James Logan ('Laird of Matjiesfontein').
Lohmann returned to England briefly in mid-1901 to manage the touring South African team — the first overseas tour by South Africa to receive first-class status. He fell ill again on the voyage back and died at Matjiesfontein on 1 December 1901, aged 36. He is buried in the Matjiesfontein cemetery; the Surrey CCC paid for his memorial. His final Test bowling figures — 112 wickets at 10.75 in 18 Tests — are still the best of any bowler with 100 Test wickets.