Wisden was born at Brighton in 1826 and apprenticed to the Sussex professional Thomas Box. He made his first-class debut for Sussex in 1846 and was almost immediately recognised as a phenomenon: at little more than five feet four inches tall, he could bowl genuinely fast and had developed a sharp off-cutter that he could land on a sixpence. The umpire Bob Thoms gave him the nickname 'Little Wonder', which stuck. The peak of his playing fame came on 15 July 1850 in the North v South match at Lord's, when in the South's second innings he bowled all ten wickets — the only instance in first-class cricket history of all ten dismissals being bowled. The feat was widely reported and turned Wisden's name into a byword for accurate fast bowling. He played for Sussex from 1846 to 1863, made occasional appearances for Kent and Middlesex, and was a foundation member of William Clarke's All-England Eleven, leaving with George Parr in 1852 to help create the rival United All-England Eleven. He was a regular tourist with the AEE around the country, played in the first English overseas tour to North America in 1859, and in 1855 opened a sports outfitters in Cranbourn Street, London. By the early 1860s rheumatism was forcing him out of the game; he retired at the end of 1863 with more than 1,000 first-class wickets at 6.66 and turned his attention to publishing. His first almanack appeared the following spring.